Application

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Altius Institute





Description

   ▸ FORGE2 is the new version of FORGE, including new stats and multiple epigenetic datasets.

▸ FORGE2 identifies tissue- or cell type-specific signal by analysing a minimum set of 5 single nucleotide polymorphisms (SNPs) for overlap with epigenetic data peaks compared to matched background SNPs and provides both graphical and tabular outputs.

▸ FORGE2 incorporates data across DNase I hypersensitive sites (DHSs), histone mark chromatin immunoprecipitation (ChIP) broadpeaks, and hidden Markov model (HMM) chromatin states.
 		   

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Credits
Breeze CE, Haugen E, Reynolds A, Teschendorff A, van Dongen J, Lan Q, et al. Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations. Genome Biology. 2022;23:13. https://doi.org/10.1186/s13059-021-02560-3

Breeze CE, Haugen E, Gutierrez-Arcelus M, Yao X, Teschendorff A, Beck S, Dunham I, et al. FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases. Genome Biology. 2024;25:3. https://doi.org/10.1186/s13059-023-03126-1