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Altius Institute


  ▸ FORGE2 is the new version of FORGE, including new stats and multiple epigenetic datasets.

▸ FORGE2 identifies tissue- or cell type-specific signal by analysing a minimum set of 5 single nucleotide polymorphisms (SNPs) for overlap with epigenetic data peaks compared to matched background SNPs and provides both graphical and tabular outputs.

▸ FORGE2 incorporates data across DNase I hypersensitive sites (DHSs), histone mark chromatin immunoprecipitation (ChIP) broadpeaks, and hidden Markov model (HMM) chromatin states.


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Breeze, CE, Haugen, E, Reynolds, A, Teschendorff, A, van Dongen, J, Lan, Q, Rothman, N, Bourque, G, Dunham, I, Beck, S, Stamatoyannopoulos J, Franceschini, N, Berndt, SI (2022). Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations. Genome Biology 23, 13. doi: 10.1186/s13059-021-02560-3
Breeze, C.E., Haugen, E., Gutierrez-Arcelus, M., Yao, X., Teschendorff, A., Beck, S., Dunham, I., Stamatoyannopoulos, J., Franceschini, N., Machiela, M., Berndt, S. (2022). FORGEdb: systematic analysis of candidate causal variants to uncover target genes and mechanisms in complex traits. bioRxiv 2022.11.14.516365. doi: 10.1101/2022.11.14.516365