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Altius Institute


  ▸ FORGE2 is the new version of FORGE, including new stats and multiple epigenetic datasets.

▸ FORGE2 identifies tissue- or cell type-specific signal by analysing a minimum set of 5 single nucleotide polymorphisms (SNPs) for overlap with epigenetic data peaks compared to matched background SNPs and provides both graphical and tabular outputs.

▸ FORGE2 incorporates data across DNase I hypersensitive sites (DHSs), histone mark chromatin immunoprecipitation (ChIP) broadpeaks, and hidden Markov model (HMM) chromatin states.


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Breeze CE, Haugen E, Reynolds AP, et al. Integrative analysis across 3,604 GWAS reveals multiple novel cell type-specific regulatory associations. Manuscript in preparation.